Description
Don't miss out on the many recreational opportunities, including an indoor pool, a steam room, and a fitness center. Additional amenities at this hotel include complimentary wireless internet access, concierge services, and a banquet hall.. Featured amenities include a business center, dry cleaning/laundry services, and a 24-hour front desk..
A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of St. Louis Union Station and City Museum. This luxury hotel is 0.4 mi (0.7 km) from Enterprise Center and 0.7 mi (1.1 km) from America's Center Convention Complex.. Distances are displayed to the nearest 0.1 mile and kilometer. Washington Avenue Historic District - 0.2 km / 0.1 mi City Museum - 0.4 km / 0.3 mi Peabody Opera House - 0.5 km / 0.3 mi Soldiers Memorial Museum - 0.6 km / 0.4 mi Enterprise Center - 0.7 km / 0.4 mi Energizer Park - 0.7 km / 0.4 mi St. Louis Union Station - 0.7 km / 0.4 mi St. Louis City Hall - 0.7 km / 0.4 mi St. Louis Aquarium at Union Station - 0.9 km / 0.5 mi St. Louis Union Station Mini Golf - 0.9 km / 0.6 mi Citygarden Sculpture Park - 0.9 km / 0.6 mi The St. Louis Wheel - 1.1 km / 0.7 mi St. Louis American Newspaper - 1.1 km / 0.7 mi America's Center Convention Complex - 1.1 km / 0.7 mi National Blues Museum - 1.3 km / 0.8 mi The nearest airports are: St. Louis Lambert Intl. Airport (STL) - 29.6 km / 18.4 mi St. Louis, MO (SUS-Spirit of St. Louis) - 41.6 km / 25.8 mi . Near St. Louis Union Station.
Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers room service (during limited hours). Wrap up your day with a drink at the bar/lounge. Cooked-to-order breakfasts are available daily from 6:30 AM to 1:00 PM for a fee..
- Other
- Air conditioning
- Heating (free of charge)
- Additional services
- Dry cleaning service
- Laundry
- Laundry Service
- Lift
- Maid
- Reception
- 24-hour reception
- Concierge service
- Entertainment
- Games room
- Pool table
- Parking
- Nearby parking
- Parking
- Valet parking
- Pets
- Pets allowed
- Smoking
- Smoke detector
- Smoking not allowed
- Wi-Fi
- Complimentary Wi-Fi
- Services
- Banquet and event room
- Breakfast in bed
- Cash machine at the hotel
- Cloakroom facilities
- Coffee machine
- Conference centre
- Hair dryer
- Indoor pool
- Iron
- Luggage storage
- Meeting room
- Private check-in / check-out
- Private pool
- Public bathroom
- Room service
- Safe
- Security
- Serviced office
- Vending machines
- Children
- Kids' board games
- Bars
- Bar
- Swimming pools
- Children’s pool
- Gym and SPA
- Gym
- Massages
- Sauna
- Spa
- Turkish bath
- Accessibility
- Facilities for people with disabilities
- Wheelchair access
- Check-in/Check-out
- Deposit:
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- General
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- Floor: #{floorNumber}
- Tourism register number:
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- Our rentals include:
- Utilities
- Cleaning
- Admin fees and taxes
Good to know
About the deposit
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Some accommodation providers may require a deposit, which is not included in the price. This deposit will be payable upon arrival and refunded in full upon departure, provided that no damage has been caused.
Additional information
Key pick-up
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Taxes included in the final price
Any local tourist tax/resort fee has to be paid on spot directly by clients, if applicable Yes No
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Very good
Based on 195 reviews
Location
Quiet in the room
Rooms
Service
Value for money
Cleanliness
This accommodation stands out for being in the heart of Saint Louis - Missouri
Showing 4 featured reviews out of 195 TripAdvisor reviews
A
ANDRE M
26/04/2026
“Top Notch”
Amazing experience! Atmosphere, amenities and service was exceptional.
C
citimomma
ny
17/05/2026
“Has potential but definitely uneven experience”
Very well designed rooms and super interesting lobby. Definitely a fun and unexpected location. However the high-end products in the hotel room in the bathroom are always empty and the dispensers do not work, which requires multiple calls to get anything resolved. Restaurants are excellent but the… more
M
Mike B
Long Island, NY
18/05/2026
“The Good, the Bad and the Ugly.”
Stayed here due to a graduation. It was an edict property from Chase travel. Overall the property was nice but except for the museum on the second floor, it has a tired look that needs to be refreshed. Or at least a coat of paint for the hallway on the third floor. Bathroom was dark and spacious… more
T
TravelerGuy802
New England
13/05/2026
“Room for improvement”
I had business in St Louis so stayed here for a few nights. St Louis could sure use the business as the city has lots of vacant buildings and signs of entrenched poverty. The room was small for the American Midwest, but perfectly fine for 1-2 people. The location is odd. The eerily quiet neighborho… more
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