Description
Don't miss out on the many recreational opportunities, including an indoor pool, a steam room, and a fitness center. Additional amenities at this hotel include complimentary wireless internet access, concierge services, and a banquet hall.. Featured amenities include a business center, dry cleaning/laundry services, and a 24-hour front desk..
A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of St. Louis Union Station and City Museum. This luxury hotel is 0.4 mi (0.7 km) from Enterprise Center and 0.7 mi (1.1 km) from America's Center Convention Complex.. Distances are displayed to the nearest 0.1 mile and kilometer. Washington Avenue Historic District - 0.2 km / 0.1 mi City Museum - 0.4 km / 0.3 mi Peabody Opera House - 0.5 km / 0.3 mi Soldiers Memorial Museum - 0.6 km / 0.4 mi Enterprise Center - 0.7 km / 0.4 mi Energizer Park - 0.7 km / 0.4 mi St. Louis Union Station - 0.7 km / 0.4 mi St. Louis City Hall - 0.7 km / 0.4 mi St. Louis Aquarium at Union Station - 0.9 km / 0.5 mi St. Louis Union Station Mini Golf - 0.9 km / 0.6 mi Citygarden Sculpture Park - 0.9 km / 0.6 mi The St. Louis Wheel - 1.1 km / 0.7 mi St. Louis American Newspaper - 1.1 km / 0.7 mi America's Center Convention Complex - 1.1 km / 0.7 mi National Blues Museum - 1.3 km / 0.8 mi The nearest airports are: St. Louis Lambert Intl. Airport (STL) - 29.6 km / 18.4 mi St. Louis, MO (SUS-Spirit of St. Louis) - 41.6 km / 25.8 mi . Near St. Louis Union Station.
Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers room service (during limited hours). Wrap up your day with a drink at the bar/lounge. Cooked-to-order breakfasts are available daily from 6:30 AM to 1:00 PM for a fee..
- Other
- Air conditioning
- Heating (free of charge)
- Additional services
- Dry cleaning service
- Laundry
- Laundry Service
- Lift
- Maid
- Reception
- 24-hour reception
- Concierge service
- Entertainment
- Games room
- Pool table
- Parking
- Nearby parking
- Parking
- Valet parking
- Pets
- Pets allowed
- Smoking
- Smoke detector
- Smoking not allowed
- Wi-Fi
- Complimentary Wi-Fi
- Services
- Banquet and event room
- Breakfast in bed
- Cash machine at the hotel
- Cloakroom facilities
- Coffee machine
- Conference centre
- Hair dryer
- Indoor pool
- Iron
- Luggage storage
- Meeting room
- Private check-in / check-out
- Private pool
- Public bathroom
- Room service
- Safe
- Security
- Serviced office
- Vending machines
- Children
- Kids' board games
- Bars
- Bar
- Swimming pools
- Children’s pool
- Gym and SPA
- Gym
- Massages
- Sauna
- Spa
- Turkish bath
- Accessibility
- Facilities for people with disabilities
- Wheelchair access
- Check-in/Check-out
- Deposit:
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- General
- Number of people: #{numberOfPersons}
- Floor: #{floorNumber}
- Tourism register number:
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- Our rentals include:
- Utilities
- Cleaning
- Admin fees and taxes
Good to know
About the deposit
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Some accommodation providers may require a deposit, which is not included in the price. This deposit will be payable upon arrival and refunded in full upon departure, provided that no damage has been caused.
Additional information
Key pick-up
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Taxes included in the final price
Any local tourist tax/resort fee has to be paid on spot directly by clients, if applicable Yes No
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Very good
Based on 207 reviews
Location
Quiet in the room
Rooms
Service
Value for money
Cleanliness
This accommodation stands out for being in the heart of Saint Louis - Missouri
Showing 5 featured reviews out of 207 TripAdvisor reviews
H
Happiness30592836834
09/08/2026
“Thank you, Mae!”
Wonderful place! Staff is especially caring and attentive. Great customer service, ambience and food. Maelisha and Drummond are amazing and highly recommend!
S
Sharon M
09/08/2026
“Fun and artistic find, amazing staff, art, pool, hot tub and sauna”
I took an unexpected trip in the midst of a bad migraine and booked the wrong weekend. No problem - theymoved my reservation up a week even though the hotel was packed for a pretty large wedding with no change in price. I asked for a quiet room away from it all and never heard 1 peep in my room. Ma… more
K
Kimberly H
02/08/2026
“My stay in the Lou”
Tiffany at the registration desk was AMAZING!!! I had a wonderful stay. I loved the amenities, although I never made it to the gym. I enjoyed swimming, steam room and sauna. Noise was a bit much I often heard kids running and yelling in the hall and stomping above me (that’s why I always request to… more
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Elizabeth R
01/08/2026
“Great dinner!”
Everything was great! Drinks, food, service- Mitch was a wonderful waiter!
T
tacksjunior44
Round Lake, Illinois
01/08/2026
“Legitimately a hotel in a museum”
This hotel is amazing. It has an entire floor museum built into the hotel which isn't just an afterthought. The athletic club downstairs was also awesome - steam room, sauna, hot tub, waterfall room.... Everything you need to wind down and relax. Finally, the Idol Wolf Restaraunt is top notch. … more
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